Trazodone and acetaminophen

Trazodone and acetaminophen DEFAULT

Trazodone, Oral Tablet

Highlights for trazodone

  1. Trazodone oral tablet is available as a generic drug. It doesn’t have a brand-name version.
  2. Trazodone only comes as a tablet you take by mouth.
  3. Trazodone is used to treat depression.

What is trazodone?

Trazodone oral tablet is a prescription drug. It’s available only as a generic drug. Generic drugs usually cost less than brand-name drugs.

Why it’s used

Trazodone is used to treat depression in adults.

How it works

Trazodone belongs to a class of drugs called antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It isn’t fully understood how trazodone works. It may increase serotonin activity in your brain. Serotonin is a chemical in your brain that can help stabilize your mood.

Trazodone oral tablet may cause drowsiness or sleepiness. You shouldn’t drive, use machinery, or do other activities that require alertness until you know how this drug affects you.

Trazodone side effects

Trazodone can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking trazodone. This list does not include all possible side effects.

For more information on the possible side effects of trazodone, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

More common side effects

The more common side effects of trazodone can include:

  • swelling
  • sleepiness
  • dizziness
  • diarrhea
  • stuffy nose
  • weight loss
  • blurred vision

These effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Thoughts of suicide and worsening depression. Symptoms include:
    • thoughts about suicide or dying
    • attempts to die by suicide
    • new or worse depression
    • new or worse anxiety
    • feeling very agitated or restless
    • panic attacks
    • insomnia (trouble sleeping)
    • new or worse irritability
    • acting aggressive, angry, or violent
    • acting on dangerous impulses
    • mania (an extreme increase in activity and talking)
    • other unusual changes in behavior or mood
  • Serotonin syndrome. Symptoms include:
    • agitation
    • confusion or trouble thinking
    • hallucinations (seeing or hearing something that isn’t there)
    • problems with coordination
    • fast heart rate
    • tight muscles
    • trouble walking
    • nausea
    • vomiting
    • diarrhea
  • Vision problems. Symptoms include:
    • eye pain
    • changes in your vision, such as blurred vision or visual disturbances
    • swelling or redness in or around your eye
  • Irregular or fast heartbeat
  • Low blood pressure. Symptoms include:
    • dizziness or fainting when you change positions, such as standing up from a sitting position
  • Unusual bruising or bleeding
  • Erection that lasts longer than 4 hours
  • Hyponatremia (low sodium in your blood). Symptoms include:
    • headache
    • weakness
    • confusion
    • trouble concentrating
    • memory problems
    • feeling unsteady when you walk

How to take trazodone

The trazodone dosage your doctor prescribes will depend on various factors. These include:

  • the type and severity of the condition you’re using the drug to treat
  • your age
  • the form of the drug you take
  • other medical conditions you may have

Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Forms and strengths

Generic: Trazodone

  • Form: oral tablet
  • Strengths: 50 mg, 100 mg, 150 mg, 300 mg

Dosage for major depressive disorder

Adult dosage (ages 18 years and older)

  • Typical starting dosage: 150 mg per day in divided doses.
  • Dosage increases: Your doctor may increase your dose by 50 mg per day every 3 or 4 days.
  • Maximum dosage: 400 mg per day in divided doses. If you’re staying in a hospital, the maximum dosage is 600 mg per day.

Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years old.

Take as directed

Trazodone oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all. If you stop taking this drug suddenly or don’t take it, your depression may not get better. You may also have withdrawal symptoms. These include anxiety, agitation, and trouble sleeping. If you need to stop taking this drug, your doctor will slowly lower your dose over time.

If you miss doses or don’t take the drug on schedule. Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much. You could have dangerous levels of trazodone in your body. Symptoms of an overdose of this drug can include:

  • an erection that lasts longer than 4 hours
  • seizures
  • changes in the way your heart functions, including QT prolongation (a heart rhythm issue that may cause chaotic or abnormal heartbeats)

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose. Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working. You should have decreased feelings of depression, and your mood should improve.

Trazodone warnings

This drug comes with various warnings.

Serotonin syndrome warning

This drug can cause a life threatening condition called serotonin syndrome. This risk is higher when you first start taking this drug or during dosage changes.

Your risk may be higher if you also take other drugs that have similar effects as trazodone, such as other drugs used to treat depression.

Symptoms of serotonin syndrome include agitation, hallucinations, confusion or trouble thinking, nausea, vomiting, and diarrhea.

They also include coordination problems, muscle twitching, stiff muscles, racing heart rate, high or low blood pressure, sweating, fever, and coma.

Call your doctor right away if you have these symptoms.

Angle-closure glaucoma warning

This drug can cause your pupils to be slightly bigger and lead to angle-closure glaucoma (a condition that causes increased pressure in your eyes). If you’re at high risk for this condition, your doctor may give you a medication to help prevent it.

Bleeding warning

Taking this drug with other medications that affect your ability to stop bleeding may increase your risk for bleeding. This includes serious, life threatening bleeding, and bleeding-related events, such as nosebleeds, bruising, or skin discoloration due to bleeding below your skin.

These drugs include warfarin, dabigatran, rivaroxaban, and pain medications called nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin.

Allergy warning

Trazodone can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your face, tongue, eyes, or mouth
  • rash, hives (itchy welts), or blisters, alone or with fever or joint pain

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction warning

Consuming drinks that contain alcohol can increase your risk for sleepiness or dizziness from trazodone. If you drink alcohol, talk to your doctor about whether alcohol use is safe for you while you take this drug.

Warnings for people with certain health conditions

For people with heart disease. Ask your doctor whether this drug is safe for you. Taking trazodone may cause irregular heartbeat and a prolonged QT interval (a heart rhythm issue that may cause chaotic or abnormal heart beats). Your doctor may watch you closely if you take this drug.

For people with angle-closure glaucoma. This drug may make your pupils bigger and may cause an angle-closure attack.

For people with a history of mania or bipolar disorder. You may have a higher risk for manic episodes. If you have a history of mania or bipolar disorder, your doctor may need to prescribe a different medication.

Warnings for other groups

For pregnant women. There haven’t been enough studies done in humans to be certain how this drug might affect a pregnancy.

Research in animals has shown negative effects to the fetus when the mother takes this drug. However, animal studies don’t always predict the way humans would respond.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus. Call your doctor right away if you become pregnant while taking this drug.

There’s a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants during pregnancy. To take part in the National Pregnancy Registry for Antidepressants, call 844-405- 6185 or visit their website.

Women who are breastfeeding. Trazodone may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

If you’re over the age of 65 years, you may be at higher risk for developing side effects while taking this drug. This includes hyponatremia (low salt levels in your blood).

For children. The safety and effectiveness of this drug haven’t been established in children. This drug shouldn’t be used in people younger than 18 years.

Trazodone may interact with other medications

Trazodone oral tablet can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Below is a list of medications that can interact with trazodone. This list does not contain all drugs that may interact with trazodone.

Before taking trazodone, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Drugs you should not use with trazodone

Do not take these drugs with trazodone. Doing so can cause dangerous effects in your body. Examples of these drugs include:

  • Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, tranylcypromine, or selegiline. You shouldn’t take trazodone with MAOIs or within 14 days of taking them. Taking these drugs together raises your risk for serotonin syndrome.

Interactions that can cause more side effects

Taking trazodone with certain medications may cause more side effects. These drugs include:

  • Central nervous system (CNS) depressants such as pentobarbital and secobarbital. Trazodone may make your response to barbiturates and other CNS depressants stronger.
  • Warfarin. Taking trazodone with warfarin can increase your risk for bleeding. Your doctor will watch you closely.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin. Trazodone may increase your risk of bleeding when used with these drugs.
  • Depression drugs, such as citalopram, fluoxetine, paroxetine, sertraline, venlafaxine, duloxetine, and St. John’s wort. Taking these drugs together may increase your risk of serotonin syndrome. This condition can be life threatening.
  • Digoxin. Taking trazodone with digoxin may increase the levels of digoxin in your body. This could increase your risk of side effects from digoxin. These include vomiting, dizziness, vision problems, and irregular heart rate. Your doctor may monitor the level of digoxin in your blood if you take these drugs together.
  • Phenytoin. Taking trazodone with phenytoin may increase the levels of phenytoin in your body. This could increase your risk for side effects from phenytoin. These include constipation, changes in mood, confusion, and balance problems. Your doctor may monitor the level of phenytoin in your blood if you take these drugs together.
  • Ketoconazole or ritonavir. The level of trazodone in your body may increase if you take it with ketoconazole, ritonavir, or other drugs that increase levels of trazodone. This can increase your risk of side effects from trazodone. These include serotonin syndrome and vision problems. Your doctor may lower your trazodone dosage if you take drugs that can increase trazodone levels.

Interactions that can make drugs less effective

Certain drugs may decrease the levels of trazodone in your body and make your dosage of trazodone less effective. You doctor may need to increase your dosage of trazodone when you take it with these drugs.

These drugs include:

  • Phenytoin and carbamazepine

Important considerations for taking trazodone

Keep these considerations in mind if your doctor prescribes trazodone oral tablet for you.


  • Take trazodone shortly after a meal or snack.
  • You should swallow this drug whole. You can also break it in half along the score line (indented line down the center of the tablet) and swallow it. Don’t chew or crush trazodone tablets.


  • Store trazodone at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
  • Keep it away from light.


A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.


  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Eye health. You may be at risk for angle-closure glaucoma. Your doctor may do an eye exam and treat you if needed.
  • Mental health and behavioral problems. You and your doctor should watch for any changes in your behavior and mood. This drug can cause new mental health and behavior issues. It can also make problems you already have worse.

Prior authorization

Many insurance companies may require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.


Trazodone (Desyrel)

You should not use trazodone if you are allergic to it.

Do not use trazodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with trazodone could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

  • liver or kidney disease;
  • heart disease, or a recent heart attack;
  • a bleeding or blood clotting disorder;
  • seizures or epilepsy;
  • narrow-angle glaucoma;
  • long QT syndrome;
  • drug addiction or suicidal thoughts; or
  • bipolar disorder (manic depression).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop trazodone without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Trazodone is not approved for use by anyone younger than 18 years old.

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Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. A list of national and international resources and hotlines to help connect you to needed health and medical services. The study is created by eHealthMe based on reports of 516 people who take Trazodone hydrochloride and Tylenol from the FDA, and is updated regularly. Unanswered Questions. Use of this site constitutes acceptance of's terms of service and privacy policy. I am kinda scared. Anyway, my primary care doctor prescribed me Trazodone. ... Can you take Tylenol pm if you have afib. The mechanism may involve inhibition of CYP450 3A4 metabolism. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. I have had a few restless nights since starting tx..but for the most part,am,thankfully,sleeping pretty well.

On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age.

I am taking Bactrim (antibiotic) for a urinary tract infection.I took the first pill last night at around 9.30 pm. Anyway, I feel like the OTC sleep aid will be hard on my liver and renal system if I take them every night for the next 5 months. It can be useful to cure your insomnia as well as slight depression that you are having. Can this cause an interaction? I read those sites, and they make sense! Subscribe to MedHelp's free newsletter for Community Support, Experience, and Guidance. Answer for question: Your name: Answers. yes. Can you take Trazodone and Tylenol PM together? The study is created by eHealthMe based on reports of 2,459 people who take Bactrim and Tylenol from the FDA, and is updated regularly. I make good decisions by relying mostly on my instincts. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. How the drugs might affect you. Well I hope you get sorted.

Does Trazodone have wierd side effects too? These medications are not usually taken together.

It contains 500 mg of acetaminophen and 25 mg of diphenhydramine. We offer this Site AS IS and without any warranties.

I am waiting to hear back from my hep C doc to check on drug interactions. I just had surgery and my doctor prescribed bactrim to me due to a shaph infection, so I am taking.

For the past 2 months I take Tylenol PM or Motrin PM (just 1.5 pills, not the recommended dose of 2), sometimes Benadryl. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. I am waiting to hear back from my … ... Can you take Bactrim and Tylenol together? Didn't find the answer you were looking for? sulfamethoxazole-trimethoprim oral brand names and other generic formulations include:. Diphenhydramine is non-habit forming and can help you fall … All rights reserved. If you're describing worst headache of your life, then you need to have someone take you to ER for brain scan. The study is created by eHealthMe based on reports of 516 people who take Trazodone hydrochloride and Tylenol from the FDA, and is updated regularly. No pharmacokinetic data are currently available; however, adverse effects such as nausea, dizziness, hypotension, and syncope may be increased. Thanks guys and gals! These common ADD/ADHD myths could already be hurting your child Since I started TX 11 weeks ago, insomnia has been a problem. These tips may up your chances of a cure. If you're reporting headaches within 2d of starting Trazodone (antidepressant w/sedating qualities) that doesn't improve/resolve w/extra strength Tylenol, (acetaminophen) then you need to report this to your prescribing doc.

For people with Obsessive-Compulsive Disorder (OCD), the COVID-19 pandemic can be particularly challenging. xoxo Reply (0) Report.

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